Annotation: This book, written for the general public, discusses sickle cell disease and trait; it is based on questions patients, parents, and others have asked the staff of the Georgia Comprehensive Sickle Cell Center at Grady Health Center in Atlanta, Georgia. Part one of the book, entitled the ABCs of sickle cell disease, contains background information on blood, genetics, genetic counseling, raising children with the disease, sickle cell trait, and medical care. Part two discusses developmental issues in stages: birth to six years of age; 6-12 years; 13-18 years; 19-25 years; 26-40 years; and adults over 40. The third part focuses on living with sickle cell disease and topics in pain assessment and management; new treatments and research; what the patient can do; and provides resources. Two appendices include information on the history of sickle cell disease and its distribution, and a bibliography. The book concludes with an index.

Contact: Hilton Publishing, 1630 45th Street, Suite 103, Munster, IN 46321, Telephone: 219-922-4868 Secondary Telephone: 866-455-1070 Fax: 219-922-6407 E-mail: info@hiltonpub.com Web Site: http://www.hiltonpub.com $16.95, plus shipping and handling. Document Number: ISBN 0-9675258-4-5.

Keywords: Blacks, Blood and lymphatic diseases, Chronic pain, Developmental stages, Genetic counseling, Genetic screening, Hematologic disorders, Patient education materials, Sickle cell disease, Sickle cell trait, Therapeutics

Annotation: These proceedings are from a conference sponsored by the New England Thalassemia Program held in Boston on November 14, 1996. They define thalassemia intermedia, present data from patients, discuss research at the National Institutes of Health on the use of sodium phenylbutyrate and hydroxyurea to stimulate fetal hemoglobin, and analyze the molecular basis of the disease. Other presentations deal with the assessment of iron overload, the use of chelation therapy, splenectomy, and infection control. Finally, there is a panel discussion about treatment approaches. The proceedings are published as a special issue of The Genetic Resource (vol 11, no. 2). [Funded by the Maternal and Child Health Bureau]

Contact: New England Thalassemia Program, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, Telephone: (617) 355-5943 Fax: (617) 355-7940 Price unknown. Document Number: ISBN 1-57285-041-8.

Keywords: Conference proceedings, Genetic disorders, Hematologic diseases, Thalassemia

Annotation: This report contains the proceedings of an international conference on thalassemia held in Bangkok, Thailand, June 30-July 3, 1985. General topics covered in volume A are: molecular biology and pathogenesis, pathophysiology, clinical manifestations and hematologic changes, cardiopulmonary defects and platelet function, hormones and minerals, and infection and immunology. Topics covered in volume B are: iron metabolism and chelation, pathology, general management, future trends in management, geographic distribution, and control.

Keywords: Hematologic diseases, Thalassemia

Annotation: This booklet is available in English, Hmong, Vietnamese, Laotian, and Khmer. It describes thalassemia and includes a physiological explanation of the disease. It explains who is affected by the disease, the range of symptoms and effects, the inheritance of the disorder, and how a diagnosis is made. The booklet discusses choices to be made if both parents are carriers, and if a prenatal diagnosis reveals thalassemia. [Funded by the Maternal and Child Health Bureau]

Contact: University of California, Irvine, Southeast Asian Genetics Program, Building 29A, Second Floor, 101 The City Drive, Orange, CA 92668, Telephone: (714) 634-6966

Keywords: Asian language materials, Hematologic diseases, Infant health, Thalassemia

Annotation: This fact sheet briefly explains the different kinds of thalassemia, effects on children, treatment, transmission, detection before birth and research being done.

Contact: March of Dimes, 1275 Mamaroneck Avenue, White Plains, NY 10605, Telephone: (914) 997-4488 Secondary Telephone: E-mail: Web Site: http://www.marchofdimes.com Out of print; new edition available from source listed. Document Number: HRSA Info. Ctr. MCHB164.

Keywords: Genetic disorders, Hematologic diseases, Thalassemia

Annotation: This article describes three new therapies for treating sickle cell anemia. These are being experimented with and involve affecting the mechanism of sickling rather than trying to control the pain. The article also discusses other management of sickle cell anemia which are dietary and antidiuretic in nature.

Contact: National Center for Education in Maternal and Child Health, Georgetown University, Box 571272, Washington, DC 20057-1272, Telephone: (202) 784-9770 Fax: (202) 784-9777 E-mail: mchgroup@georgetown.edu Web Site: http://www.mchlibrary.org Photocopy available at no charge. Document Number: HRSA Info. Ctr. MCHB140.

Keywords: Anemia, Hematologic diseases, Sickle cell disease

Annotation: This paper presents an attempt to meet a request by hemophilia diagnostic and treatment centers for guidance to assist them in meeting the requirement for mental health services as part of comprehensive care for patients and their families. The guidance consists of listing the psychological and social components in a comprehensive hemophilia care center at the primary, secondary and tertiary care levels. Professional staff roles and related services are also discussed in terms of what is desirable for effective care.

Contact: National Center for Education in Maternal and Child Health, Georgetown University, Box 571272, Washington, DC 20057-1272, Telephone: (202) 784-9770 Fax: (202) 784-9777 E-mail: mchgroup@georgetown.edu Web Site: http://www.mchlibrary.org Photocopy available at no charge. Document Number: HRSA Info. Ctr. MCHB107; DHHS (HSA) 81-5247A.

Keywords: Hematologic diseases, Hemophilia

Annotation: This short booklet briefly describes what Cooley's anemia is and emphasizes that a blood test before one becomes pregnant is the only way to know if one is a carrier of the trait. The brochure advises that it is up to the reader, especially if he is of Mediterranean descent, to obtain the blood test; it will not be done as a matter of course.

Contact: National Center for Education in Maternal and Child Health, Georgetown University, Box 571272, Washington, DC 20057-1272, Telephone: (202) 784-9770 Fax: (202) 784-9777 E-mail: mchgroup@georgetown.edu Web Site: http://www.mchlibrary.org Photocopy available at no charge. Document Number: DHHS (NIH) 80-2026.

Keywords: Hematologic diseases, Thalassemia

Annotation: This booklet explains the problem of Rh isoimmunization from when it was first discovered in 1940. It discusses the pathogenesis and treatment, mortality and morbidity associated with Rh incompatibility, prevention with Rh immunoglobulin, implications of abortion and Rh isoimmunization, and the clinical application of Rh immunoglobulin.

Contact: National Center for Education in Maternal and Child Health, Georgetown University, Box 571272, Washington, DC 20057-1272, Telephone: (202) 784-9770 Fax: (202) 784-9777 E-mail: mchgroup@georgetown.edu Web Site: http://www.mchlibrary.org Photocopy available at no charge. Document Number: HRSA Info. Ctr. MCH; DHEW (HSA) 77-5208.

Keywords: Hematologic diseases, RH isoimmunization

Annotation: This conference report discusses granulocytopoiesis, humoral control, erythrokinetics, the role of DNA reutilization in kinetics of the thymolymphatic system, embryonic thymus development and thymic function, the thymus and its relationship to other proliferative systems, blood cell chimerism, bone marrow transplantation, pathogenesis of bone marrow failure associated with chloramphenicol, pathogenesis of bone marrow failure associated with phenothiazine derivatives, aplastic anemia in children, association of paroxysmal nocturnal hemoglobinuria and aplastic anemia, congenital and genetically influenced syndromes associated with aplastic anemia, and the role and results of the American Medical Association study group on blood dyscrasias.

Keywords: Anemia, Children with special health care needs, Conferences, Hematologic diseases