
Maternal and Child Health Library
MCH Alert: Focus on Infant Mortality is developed by the Maternal
and Child Health Library in collaboration with the National Sudden
and Unexpected Infant/Child and Pregnancy Loss Resource Center at
Georgetown University. This
and past issues are available online
at http://www.mchlibrary.info/alert/archives.html and http://www.sidscenter.org/alert/archives.html.
May 28, 2010
Multimedia Featured Resource: The National Sudden Unexpected
Infant-Child Death and Pregnancy Loss Resource Center's Web site
contains archived and resource materials from the May 20, 2010, Webinar
titled New Research into Sudden Infant Death: Unraveling the Mystery of
SIDS. The Webinar was the second in a series of quarterly Webinars
co-sponsored by the Association of SIDS and Infant Mortality
Professionals and the Association of Maternal and Child Health
Programs. Topics included the role of the postmortem evaluation in
research into SIDS and seratonergic deficiencies in SIDS. The Webinar
archive and resources are available at http://www.sidscenter.org/podcasts/2010/asip_amchp/2_webinar.html
1. Report Presents Infant Mortality Data
2. Article Examines Infant Death Among Ohio Infants Born
at 32 to 41 Weeks' Gestation
3. Study Furthers Evidence on the Association Between
Fetal Loss and the Risk of Relationship Dissolution
4. Authors Estimate the Risk of Stillbirth and Prenatal
Cigarette Smoking Among Adolescents
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1. REPORT PRESENTS INFANT MORTALITY DATA
Infant Mortality Statistics from the 2006 Period Linked Birth/Infant
Death Data Set provides descriptive tabulations of infant mortality
data by a variety of maternal and infant characteristics. The report,
published in National Vital Statistics Reports on April 30, 2010,
contains data based on birth and infant death certificates registered
in all states, the District of Columbia, Puerto Rico, the Virgin
Islands, and Guam. Content includes methods, results, and discussion
about trends in infant mortality. Discussion and tables address infant
mortality by race and Hispanic origin of mother, state, sex of infant,
multiple births, age at death, period of gestation, birthweight,
prenatal care, maternal age, maternal education, live birth order,
marital status, nativity, maternal smoking, leading causes of infant
death, and preterm-related causes of death. The information is useful
for understanding the basic relationships between risk factors and
infant mortality, unadjusted for possible effects of other variables.
The report is available at http://www.cdc.gov/nchs/data/nvsr/nvsr58/nvsr58_17.pdf
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2. ARTICLE EXAMINES INFANT DEATH AMONG OHIO INFANTS BORN AT 32 TO 41
WEEKS' GESTATION
"The current study of a large cohort of Ohio births strongly suggests
that immaturity may be a better predictor of infant risk than
birthweight," write the authors of an article published in the American
Journal of Obstetrics and Gynecology online (ahead of print) on April
26, 2010. Prematurity is the leading cause of infant death defined as
death of a live-born infant before age 1. Among preterm infants, risk
of infant death increases progressively as gestational age at birth
decreases. The purpose of the study described in this article was to
determine adjusted infant mortality rates for infants born in Ohio from
2003 to 2005 for each week of gestational age at birth from 32 to 41
weeks.
The retrospective study used existing electronic birth certificates and
infant death certificates for birth years 2003-2005 provided by the
Ohio Department of Health. Death certificates for children who died
before age 1 were manually linked to their respective birth
certificates using variables common to both databases. The linked
birth-death database was used to calculate both unadjusted and adjusted
gestational-age-specific infant mortality rates.
The authors found that
- The Ohio infant mortality rate for all births regardless of
gestational age for the study period was 7.3 per 1,000 live births.
Unadjusted, gestational-age-specific infant mortality rates increased
progressively from 2.2 per 1,000 live births at 39 or 40 weeks'
gestational age to 16.3 per 1,000 live births at 32 weeks.
- In adjusted analyses, the odds ratio for infant death increased
progressively as gestational age decreased from 38 to 32 weeks.
- For infants born at 32 to 33 weeks, the adjusted infant mortality
rate was approximately 12 deaths for every 1,000 live births. For those
born at 34, 35, 36-37, and 38 weeks, the rate was approximately 9, 6,
4, and 3 deaths for every 1,000 live births, respectively, compared
with 2 infant deaths for every 1,000 live births at 39-40 weeks.
- As a percentage of all death causes at each gestational age,
sudden infant death syndrome and intentional injury appeared to
increase, whereas perinatal asphyxia or cerebral palsy and congenital
malformations appeared to decrease as gestational age increased from 32
to 41 weeks.
The authors conclude that "decisions to deliver before 39 weeks should
consider increased likelihood of infant death that may be unrelated to
fetal malformations or maternal illness."
Donovan EF, Besi J, Paulson J, et al. 2010. Infant death among Ohio
resident infants born at 32 to 41 weeks of gestation. American Journal
of Obstetrics and Gynecology [published online ahead of print on April
26, 2010]. Abstract available at http://www.ajog.org/article/S0002-9378%2810%2900101-8/abstract
Readers: More information is available from the following MCH Library
resource:
- Infant Mortality and Pregnancy Loss: Knowledge Path at
http://mchlibrary.info/KnowledgePaths/kp_infmort.html
- Prematurity: Bibliography of Materials from MCHLine at
http://mchlibrary.info/databases/bibliography.php?target=auto_search_premature
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3. STUDY FURTHERS EVIDENCE ON THE ASSOCIATION BETWEEN FETAL LOSS AND
THE RISK OF RELATIONSHIP DISSOLUTION
"This is the first national study to establish that parental
relationships have a higher risk of dissolving after a miscarriage or
stillbirth, compared with a live birth," state the authors of an
article published in the May 2010 issue of Pediatrics. Miscarriage
(loss of a fetus before 20 weeks' gestation) and stillbirth (loss at 20
or more weeks but before birth) may be traumatic events for surviving
parents. At present, there is limited information about what happens to
marriages of parents who experience miscarriages or stillbirths, and
even less about outcomes for cohabitating parents. The study described
in the article used data from a national U.S. survey on relationships
and reproductive health to evaluate marriage and cohabitation outcomes
for couples who experienced a live birth or fetal death at any
gestational age of pregnancy.
Data for the study were drawn from Cycle 6 (2002) of the National
Survey of Family Growth (NSFG). The survey included information on
family and reproductive histories from interviews with 7,643 females
(ages 15-44). The present study excluded women who had never been
pregnant and those who were separated, divorced, widowed, or not
cohabitating. (Cohabitations in the NSFG were defined as women living
with a male intimate partner.) The outcomes of interest included live
births, miscarriages, and stillbirth. The analyses examined the
relationship status of the mother at the time that the pregnancy ended
and then evaluated the duration and outcome of that specific
relationship over time. The research controlled for relationship
duration before birth and subject-level variables associated with
relationship survival.
The authors found that
- Of 7,770 pregnancies, 6,409 (82 percent) ended in live births,
1,225 (16 percent) in miscarriages, and 136 (2 percent) in stillbirths.
- Compared with women with live births, women with fetal losses
were significantly more likely to have higher household incomes and to
be cohabitating rather than married. White women and women with higher
educational attainment were more likely to have a miscarriage, whereas
black women and women with lower educational attainment were more
likely to have a stillbirth. Women with losses also tended to be
slightly older than women with live births at the time that their
current relationship ended.
- Even when controlling for known risk factors for relationship
dissolution (lower maternal age, cohabitation, previous live birth,
black race, and shorter duration of relationship), women with
miscarriages and stillbirths had higher risks of their relationships
ending, compared with women whose pregnancies ended in live births.
- Most of the effect after miscarriages occurred between 1.5 and 3
years after the loss. In contrast, the effect for stillbirths persisted
for up to 9 years after the loss.
"This study finds that married and cohabitating parents are at
significantly great hazard for separation after miscarriage, and this
risk is even higher after stillbirth," conclude the authors. They
suggest, "additional research is warranted to identify the specific
risks and protective factors that influence relationship survival and
to evaluate whether specific bereavement interventions can improve
long-term marriage and cohabitation outcomes after miscarriages and
stillbirths."
Gold KJ, Sen A, Hayward RA. 2010. Marriage and cohabitation outcomes
after pregnancy loss. Pediatrics 125(5):e1202-1207. Abstract available
at http://pediatrics.aappublications.org/cgi/content/abstract/125/5/e1202
Readers: More information is available from the National Sudden and
Unexpected Infant/Child Death and Pregnancy Loss Resource Center at
Georgetown University as follows:
- Pregnancy Loss at
http://www.sidscenter.org/PregnancyLoss.html
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4. AUTHORS ESTIMATE THE RISK OF STILLBIRTH AND PRENATAL CIGARETTE
SMOKING AMONG ADOLESCENTS
"To our knowledge, this is the first report suggesting increased risk
of intrapartum stillbirth with intrauterine nicotine exposure among
adolescents, an established obstetric high-risk entity," state the
authors of an article published in the June 2010 issue of the Journal
of Pediatric and Adolescent Gynecology. Adolescent pregnancy and
smoking are interrelated social issues that have been extensively
investigated by researchers, but their combined contribution to adverse
outcomes has not been previously reported. The relationship between
smoking during pregnancy among adolescents and the occurrence of
stillbirth (fetal death at 20 or more weeks' gestation) remains poorly
understood. In addition, most published studies do not distinguish
between fetal death that took place during labor (intrapartum
stillbirth) and fetal death that occurred prior to the onset of labor
(antepartum stillbirth). The article presents findings from a study to
examine the relationship between smoking during pregnancy and the
occurrence of intrapartum stillbirth (fetal death at 20 or more weeks'
gestation that took place during labor) among adolescent mothers.
Data for the study were drawn from the Missouri maternally linked
cohort data files from 1978 through 1997. This dataset links birth
certificate data on siblings to their biologic mothers. Information on
maternal age and smoking habits during pregnancy are routinely recorded
on the birth certificates based on the mother's response following
delivery. Maternal age was categorized into three subgroups: younger
adolescents (ages 14 and under), older adolescents (ages 15-19), and
mature mothers (ages 20-24). The analysis assessed differences in
baseline sociodemographic characteristics (smoking habits, marital
status, educational status, body mass index, and adequacy of prenatal
care) among the three maternal age categories. The researchers also
compared maternal subgroups for the presence of common obstetric
complications (anemia, insulin-dependent diabetes mellitus, other types
of diabetes mellitus, chronic hypertension, preeclampsia, eclampsia,
abruptio placenta, and placenta previa). Stillbirth rates were computed
to determine differences in sociodemographic characteristics and
maternal pregnancy complications across groups. Risk estimates were
also generated. Potential confounders were included to obtain
independent measures of association between intrauterine tobacco toxin
exposure and the risk of total, antepartum, and intrapartum stillbirth
in each maternal age group.
The authors found that
- Approximately 32 percent (N=205,887) of the total 633,849
singleton births analyzed were to adolescents.
- The overall prevalence of smoking was 31.2 percent, with the
lowest prevalence (14.1 percent) among younger adolescents and the
highest (31.7 percent) among older adolescents.
- The prevalence of anemia, eclampsia, and pre-eclampsia was
highest among adolescents ages 14 and under.
- The risk of intrapartum stillbirth among smokers decreased as
maternal age increased.
"There may be a need to develop appropriate information, education and
communication messages targeted to this demographic group," state the
authors. "Our results . . . ," they conclude, "could serve as an
additional incentive for mothers to quit smoking."
Aliyu MH, Salihu HM, Alio AP, et al. 2010. Prenatal smoking among
adolescents and risk of fetal demise before and during labor. Journal
of Pediatric and Adolescent Gynecology 23(3):129-135. Abstract
available at http://www.sciencedirect.com/science/article/B6W68-4YC8RKG-1/2/cbe6ff61f13c61b0e706ca2fc1d96788
Readers: More information is available from the following MCH Library
resources:
- Adolescent Prenatal Care: Bibliography of Materials from MCHLine at
http://mchlibrary.info/databases/bibliography.php?target=auto_search_adolprenatal
- Smoking During Pregnancy: Bibliography of Materials from MCHLine at
http://mchlibrary.info/databases/bibliography.php?target=auto_search_smokingpreg
Information is also available from the National Sudden and Unexpected
Infant/Child Death and Pregnancy Loss Resource Center at Georgetown
University as follows:
- Stillbirth at
http://sidscenter.org/AZtopics/S.html#s15
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MCH Alert © 1998-2010 by National Center for Education in Maternal
and
Child Health and Georgetown University. MCH Alert: Focus on Infant
Mortality is produced by
Maternal and Child Health Library at the National Center for Education
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(U02MC00001 and U48MC08717) with the Maternal and Child Health Bureau,
Health
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Please contact us at the address below.
EDITOR/ADMINISTRATOR: Jolene Bertness, M.Ed.
CO-EDITOR: Tracy Lopez, M.S.L.S.
COPYEDITOR/WRITER: Ruth Barzel, M.A.
WRITER: Beth DeFrancis, M.L.S.
MCH Alert
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