MCH Alert: Focus on Infant Mortality


Maternal and Child Health Library

MCH Alert: Focus on Infant Mortality is developed by the Maternal and Child Health Library in collaboration with the National Sudden and Unexpected Infant/Child and Pregnancy Loss Resource Center at Georgetown University. This and past issues are available online at http://www.mchlibrary.info/alert/archives.html and http://www.sidscenter.org/alert/archives.html.


May 28, 2010

Multimedia Featured Resource: The National Sudden Unexpected Infant-Child Death and Pregnancy Loss Resource Center's Web site contains archived and resource materials from the May 20, 2010, Webinar titled New Research into Sudden Infant Death: Unraveling the Mystery of SIDS. The Webinar was the second in a series of quarterly Webinars co-sponsored by the Association of SIDS and Infant Mortality Professionals and the Association of Maternal and Child Health Programs. Topics included the role of the postmortem evaluation in research into SIDS and seratonergic deficiencies in SIDS. The Webinar archive and resources are available at http://www.sidscenter.org/podcasts/2010/asip_amchp/2_webinar.html

1. Report Presents Infant Mortality Data
2. Article Examines Infant Death Among Ohio Infants Born at 32 to 41 Weeks' Gestation
3. Study Furthers Evidence on the Association Between Fetal Loss and the Risk of Relationship Dissolution
4. Authors Estimate the Risk of Stillbirth and Prenatal Cigarette Smoking Among Adolescents

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1. REPORT PRESENTS INFANT MORTALITY DATA

Infant Mortality Statistics from the 2006 Period Linked Birth/Infant Death Data Set provides descriptive tabulations of infant mortality data by a variety of maternal and infant characteristics. The report, published in National Vital Statistics Reports on April 30, 2010, contains data based on birth and infant death certificates registered in all states, the District of Columbia, Puerto Rico, the Virgin Islands, and Guam. Content includes methods, results, and discussion about trends in infant mortality. Discussion and tables address infant mortality by race and Hispanic origin of mother, state, sex of infant, multiple births, age at death, period of gestation, birthweight, prenatal care, maternal age, maternal education, live birth order, marital status, nativity, maternal smoking, leading causes of infant death, and preterm-related causes of death. The information is useful for understanding the basic relationships between risk factors and infant mortality, unadjusted for possible effects of other variables. The report is available at http://www.cdc.gov/nchs/data/nvsr/nvsr58/nvsr58_17.pdf

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2. ARTICLE EXAMINES INFANT DEATH AMONG OHIO INFANTS BORN AT 32 TO 41 WEEKS' GESTATION

"The current study of a large cohort of Ohio births strongly suggests that immaturity may be a better predictor of infant risk than birthweight," write the authors of an article published in the American Journal of Obstetrics and Gynecology online (ahead of print) on April 26, 2010. Prematurity is the leading cause of infant death defined as death of a live-born infant before age 1. Among preterm infants, risk of infant death increases progressively as gestational age at birth decreases. The purpose of the study described in this article was to determine adjusted infant mortality rates for infants born in Ohio from 2003 to 2005 for each week of gestational age at birth from 32 to 41 weeks.

The retrospective study used existing electronic birth certificates and infant death certificates for birth years 2003-2005 provided by the Ohio Department of Health. Death certificates for children who died before age 1 were manually linked to their respective birth certificates using variables common to both databases. The linked birth-death database was used to calculate both unadjusted and adjusted gestational-age-specific infant mortality rates.

The authors found that
The authors conclude that "decisions to deliver before 39 weeks should consider increased likelihood of infant death that may be unrelated to fetal malformations or maternal illness."

Donovan EF, Besi J, Paulson J, et al. 2010. Infant death among Ohio resident infants born at 32 to 41 weeks of gestation. American Journal of Obstetrics and Gynecology [published online ahead of print on April 26, 2010]. Abstract available at http://www.ajog.org/article/S0002-9378%2810%2900101-8/abstract

Readers: More information is available from the following MCH Library resource:

- Infant Mortality and Pregnancy Loss: Knowledge Path at
http://mchlibrary.info/KnowledgePaths/kp_infmort.html

- Prematurity: Bibliography of Materials from MCHLine at
http://mchlibrary.info/databases/bibliography.php?target=auto_search_premature

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3. STUDY FURTHERS EVIDENCE ON THE ASSOCIATION BETWEEN FETAL LOSS AND THE RISK OF RELATIONSHIP DISSOLUTION

"This is the first national study to establish that parental relationships have a higher risk of dissolving after a miscarriage or stillbirth, compared with a live birth," state the authors of an article published in the May 2010 issue of Pediatrics. Miscarriage (loss of a fetus before 20 weeks' gestation) and stillbirth (loss at 20 or more weeks but before birth) may be traumatic events for surviving parents. At present, there is limited information about what happens to marriages of parents who experience miscarriages or stillbirths, and even less about outcomes for cohabitating parents. The study described in the article used data from a national U.S. survey on relationships and reproductive health to evaluate marriage and cohabitation outcomes for couples who experienced a live birth or fetal death at any gestational age of pregnancy.

Data for the study were drawn from Cycle 6 (2002) of the National Survey of Family Growth (NSFG). The survey included information on family and reproductive histories from interviews with 7,643 females (ages 15-44). The present study excluded women who had never been pregnant and those who were separated, divorced, widowed, or not cohabitating. (Cohabitations in the NSFG were defined as women living with a male intimate partner.) The outcomes of interest included live births, miscarriages, and stillbirth. The analyses examined the relationship status of the mother at the time that the pregnancy ended and then evaluated the duration and outcome of that specific relationship over time. The research controlled for relationship duration before birth and subject-level variables associated with relationship survival.

The authors found that
"This study finds that married and cohabitating parents are at significantly great hazard for separation after miscarriage, and this risk is even higher after stillbirth," conclude the authors. They suggest, "additional research is warranted to identify the specific risks and protective factors that influence relationship survival and to evaluate whether specific bereavement interventions can improve long-term marriage and cohabitation outcomes after miscarriages and stillbirths."

Gold KJ, Sen A, Hayward RA. 2010. Marriage and cohabitation outcomes after pregnancy loss. Pediatrics 125(5):e1202-1207. Abstract available at http://pediatrics.aappublications.org/cgi/content/abstract/125/5/e1202

Readers: More information is available from the National Sudden and Unexpected Infant/Child Death and Pregnancy Loss Resource Center at Georgetown University as follows:

- Pregnancy Loss at
http://www.sidscenter.org/PregnancyLoss.html

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4. AUTHORS ESTIMATE THE RISK OF STILLBIRTH AND PRENATAL CIGARETTE SMOKING AMONG ADOLESCENTS

"To our knowledge, this is the first report suggesting increased risk of intrapartum stillbirth with intrauterine nicotine exposure among adolescents, an established obstetric high-risk entity," state the authors of an article published in the June 2010 issue of the Journal of Pediatric and Adolescent Gynecology. Adolescent pregnancy and smoking are interrelated social issues that have been extensively investigated by researchers, but their combined contribution to adverse outcomes has not been previously reported. The relationship between smoking during pregnancy among adolescents and the occurrence of stillbirth (fetal death at 20 or more weeks' gestation) remains poorly understood. In addition, most published studies do not distinguish between fetal death that took place during labor (intrapartum stillbirth) and fetal death that occurred prior to the onset of labor (antepartum stillbirth). The article presents findings from a study to examine the relationship between smoking during pregnancy and the occurrence of intrapartum stillbirth (fetal death at 20 or more weeks' gestation that took place during labor) among adolescent mothers.

Data for the study were drawn from the Missouri maternally linked cohort data files from 1978 through 1997. This dataset links birth certificate data on siblings to their biologic mothers. Information on maternal age and smoking habits during pregnancy are routinely recorded on the birth certificates based on the mother's response following delivery. Maternal age was categorized into three subgroups: younger adolescents (ages 14 and under), older adolescents (ages 15-19), and mature mothers (ages 20-24). The analysis assessed differences in baseline sociodemographic characteristics (smoking habits, marital status, educational status, body mass index, and adequacy of prenatal care) among the three maternal age categories. The researchers also compared maternal subgroups for the presence of common obstetric complications (anemia, insulin-dependent diabetes mellitus, other types of diabetes mellitus, chronic hypertension, preeclampsia, eclampsia, abruptio placenta, and placenta previa). Stillbirth rates were computed to determine differences in sociodemographic characteristics and maternal pregnancy complications across groups. Risk estimates were also generated. Potential confounders were included to obtain independent measures of association between intrauterine tobacco toxin exposure and the risk of total, antepartum, and intrapartum stillbirth in each maternal age group.

The authors found that
"There may be a need to develop appropriate information, education and communication messages targeted to this demographic group," state the authors. "Our results . . . ," they conclude, "could serve as an additional incentive for mothers to quit smoking."

Aliyu MH, Salihu HM, Alio AP, et al. 2010. Prenatal smoking among adolescents and risk of fetal demise before and during labor. Journal of Pediatric and Adolescent Gynecology 23(3):129-135. Abstract available at http://www.sciencedirect.com/science/article/B6W68-4YC8RKG-1/2/cbe6ff61f13c61b0e706ca2fc1d96788

Readers: More information is available from the following MCH Library resources:

- Adolescent Prenatal Care: Bibliography of Materials from MCHLine at
http://mchlibrary.info/databases/bibliography.php?target=auto_search_adolprenatal

- Smoking During Pregnancy: Bibliography of Materials from MCHLine at
http://mchlibrary.info/databases/bibliography.php?target=auto_search_smokingpreg

Information is also available from the National Sudden and Unexpected Infant/Child Death and Pregnancy Loss Resource Center at Georgetown University as follows:

- Stillbirth at
http://sidscenter.org/AZtopics/S.html#s15

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MCH Alert © 1998-2010 by National Center for Education in Maternal and Child Health and Georgetown University. MCH Alert: Focus on Infant Mortality is produced by Maternal and Child Health Library at the National Center for Education in Maternal and Child Health at Georgetown University under its cooperative agreements (U02MC00001 and U48MC08717) with the Maternal and Child Health Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services. The Maternal and Child Health Bureau reserves a royalty-free, nonexclusive, and irrevocable right to use the work for federal purposes and to authorize others to use the work for federal purposes.
 
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The editors welcome your submissions, suggestions, and questions. Please contact us at the address below.

EDITOR/ADMINISTRATOR: Jolene Bertness, M.Ed.
CO-EDITOR: Tracy Lopez, M.S.L.S.
COPYEDITOR/WRITER: Ruth Barzel, M.A.
WRITER: Beth DeFrancis, M.L.S.

MCH Alert
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