
Maternal and Child Health Library
MCH Alert: Focus on Infant Mortality is developed by the Maternal
and Child Health Library in collaboration with the National Sudden
Infant Death Resource Center. This and past issues are available online
at http://www.mchlibrary.info/alert/archives.html and http://www.sidscenter.org/alert/archives.html.
July 25, 2008
1. Report Presents Current Information and Trends on the
Nation's Health System Performance
2. State Analysis Assesses Relationship Between
Pre-Pregnancy Maternal Obesity and Risk of Infant Death
3. Study Investigates Alcohol Consumption During
Pregnancy and the Risk of Early Fetal Death
4. Authors Examine How Sudden or Unexpected Deaths May Be
Particularly Difficult for Physicians
5. Article Identifies Maternal and Infant Characteristics
Associated with Infant Sleep Positioning
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1.REPORT PRESENTS CURRENT INFORMATION AND TRENDS ON THE NATION'S
HEALTH SYSTEM PERFORMANCE
"Across 37 indicators of performance, the U.S. achieves an overall
score of 65 out of a possible 100 when comparing national averages with
benchmarks of best performance achieved internationally and within the
United States," state the authors of a report published by the
Commonwealth Fund. The report examines key indicators of national
health system performance and compares national performance for each
indicator against benchmark levels achieved by top-performing groups
within the United States or other countries.
The 2008 scorecard uses the same framework, methods, and set of
performance indicators included in the first scorecard, which was
published in 2006. The updated analyses compared baseline and current
national averages, as well as the change in the range of performance,
in five core dimensions: healthy lives, quality of care, health care
access, efficiency of the health system, and equity in the health
system. System capacity to innovate and improve was also examined.
For infant mortality, the authors found that
- The rate of infants born in the United States who die before
their first birthday improved slightly from 2002 to 2004 (from 7.0 to
6.8 deaths per 1,000 live births), thus returning to earlier levels.
Yet, the U.S. average remains well above rates in the states and
countries with the lowest rates.
- Rates of infant mortality in the worst-performing states are more
than twice those in benchmark states.
- The gap between leading and lagging states grew wider in 2004, as
states with the highest rates -- primarily poor and located in the
South -- experienced an increase in infant mortality.
- The United States ranked last among eight industrialized
countries that report infant mortality using the same methodology, with
a national rate more than double that of the leading countries (2.8 to
3.1 deaths per 1,000 live births in Japan, Iceland, and Sweden in 2004).
"Overall, performance has not improved since the first National
Scorecard was issued in 2006," state the authors, concluding that "new
national policies that take a coherent, whole-system, population view
are essential for the nation's future health and economic security."
Commonwealth Fund Commission on a High Performance Health System. Why
not the best? Results from the National Scorecard on U.S. Health System
Performance, 2008. New York, NY: Commonwealth Fund. Available at http://www.commonwealthfund.org/publications/publications_show.htm?doc_id=692682.
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2. STATE ANALYSIS ASSESSES RELATIONSHIP BETWEEN PRE-PREGNANCY MATERNAL
OBESITY AND RISK OF INFANT DEATH
"This analysis indicates that maternal obesity is associated with
increased odds of infant death," state the authors of an article
published in the July-August 2008 issue of Public Health Reports.
Consistent with the increasing focus on weight and health outcomes for
the general population, maternal pre-pregnancy weight is also being
assessed for its impact on perinatal health outcomes. In March 2004,
Florida implemented a revised birth record that includes maternal
height and pre-pregnancy weight. The addition of these two measures
made it possible to conduct population-based analyses using body mass
index (BMI). The purpose of the analysis, as presented in the article,
was to assess and quantify the relationship between pre-pregnancy BMI
and risk of infant death for the 2004 Florida birth cohort.
Data were drawn from the Florida resident birth records for the period
March-December 2004. A total of 166,301 resident birth records were
linked to 1,015 infant death records for the analysis. BMI calculations
were used to classify maternal pre-pregnancy weight into five
categories as defined by clinical guidelines: underweight, normal,
overweight, obese, and morbidly obese. Infant death was used as the
dependent variable and the BMI categories as dummy variables in the
first model. Maternal race, marital status, age, education, tobacco
use, first birth, and trimester of entry into prenatal care were
included in subsequent models to adjust for potential confounders.
These variables were also assessed as potential effect modifiers for
the BMI variables. The extent of the potential influence of maternal
diabetes mellitus, hypertension, and preeclampsia was also determined
by comparing adjusted odds rations (AORs) for women without the
specified conditions to the AORs for all women.
The authors found that
- Infants born to women who were obese had odds of infant death
that were 23% higher than the odds for the reference group of infants
born to women with normal BMIs.
- The association between maternal pre-pregnancy weight and infant
death was more pronounced for infants born to women classified as
morbidly obese, with odds of infant death that were 70% higher than
odds for the reference group.
- The results were not substantially affected by presence or
absence of the specified maternal conditions as recorded on the birth
record.
- Only the maternal race variable was associated with statistically
significant effect modification (AORs were significantly different for
black vs. non-black women).
"The integration of an important component of preconception health and
obesity prevention into effective community-based interventions may
lead to beneficial outcomes for the overall population, including women
of childbearing age," the authors conclude.
Thompson DR, Clark CL, Wood B, et al. 2008. Maternal obesity and risk
of infant death based on Florida birth records for 2004. Public Health
Reports 123(4):487-493. Abstract available at http://www.publichealthreports.org/userfiles/123_4/487-493.pdf.
Readers: More information is available from the following MCH Library
resources:
-Infant Mortality: Knowledge Path at
http://www.mchlibrary.info/KnowledgePaths/kp_infmort.html
-Preconception and Pregnancy: Knowledge Path at
http://www.mchlibrary.info/KnowledgePaths/kp_pregnancy.html
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3. STUDY INVESTIGATES ALCOHOL CONSUMPTION DURING PREGNANCY AND THE RISK
OF EARLY FETAL DEATH
"In this large retrospective cohort study of more than 650,000
pregnancies, we report elevated risks of stillbirth among mothers who
admit to alcohol ingestion during pregnancy," state the authors of an
article published in the August 2008 issue of Alcohol. Alcohol intake
during pregnancy is correlated with myriad adverse birth outcomes. The
validity of previous studies of the relationship between maternal
alcohol intake and fetal death (i.e., stillbirth) has been questioned
owing to study-design considerations, small sample sizes, errors in
classification of exposure, and failure to account for confounding
factors. Finally, most published studies of maternal drinking and fetal
death do not distinguish between fetal deaths that occur at different
stages of pregnancy. The article presents findings from a study to
investigate the independent association between alcohol consumption
during pregnancy and early fetal death using a large population-based
data set.
Data for the study were drawn from the Missouri maternally linked
cohort data files for the period 1989-1997. In this data set, siblings
are linked to their biologic mothers using unique identifiers.
Following delivery (live birth or fetal death), information was
obtained from the women regarding sociodemographic factors (including
alcohol intake during pregnancy) and other pregnancy-related
experiences. The analysis included only births within the gestational
age range of 20-44 weeks, separated into categories of early (less than
28 weeks' gestation) and late (28 or more weeks' gestation) fetal
death. The analyses determined differences in sociodemographic
characteristics and maternal pregnancy complications between
nondrinking and drinking women, with adjusted estimates derived by
using nondrinking women as the reference group.
The authors found that
- A total of 3,508 counts of fetal death were identified in the
entire study sample, yielding a fetal death rate of 5.4 per 1,000; the
rate among drinking women was 8.3 per 1,000, and the rate among the
reference group (nondrinking women) was 5.3 per 1,000.
- The risk of fetal death was 40% higher among drinking women
compared to nondrinking women. Notably, the risk of early fetal death
was 80% higher among drinking women compared to nondrinking women,
whereas the risk of late fetal death exhibited a 20% increase that did
not reach statistical significance.
- Among women who consumed five or more drinks per week during
pregnancy, the risk of fetal death was 70% higher, compared to
nondrinking women.
- The elevated risk for early or late fetal death among drinking
women did not reach statistical significance when broken down by level
of alcohol intake.
- The greatest risk for experiencing fetal death, early or late,
was exhibited among women who reported drinking during pregnancy but
failed to provide information on the number of drinks they consumed per
week.
"The exact pathway by which alcohol predisposes to stillbirth remains
to be determined," state the authors. However, they conclude, "our
findings will prove beneficial in counseling pregnant mothers or women
intending to conceive on the risks associated with alcohol abuse in
pregnancy."
Aliyu MH, Wilson RE, Zoorob R, et al. 2008. Alcohol consumption during
pregnancy and the risk of early stillbirth among singletons. Alcohol
42(5):369-374. Abstract available at http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T40-4SSGCJS-2&_user=655954&_coverDate=08%2F31%2F2008&_rdoc=3&_fmt=high&_orig=browse&_srch=doc-info(%23toc%234960%232008%23999579994%23693781%23FLA%23display%23Volume)&_cdi=4960&_sort=d&_docanchor=&_ct=10&_acct=C000035538&_version=1&_urlVersion=0&_userid=655954&md5=d4ea985c69903a85fab5a5cffb8fce35.
Readers: More information is available from the following MCH Library
resource:
- Substance Use During Pregnancy: Bibliography at
http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_subusepreg.html&-MaxRecords=all&-DoScript=auto_search_subusepreg&-search
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4. AUTHORS EXAMINE HOW SUDDEN OR UNEXPECTED DEATHS MAY BE PARTICULARLY
DIFFICULT FOR PHYSICIANS
"This national survey reveals that perinatal death has a profound
effect on delivering obstetricians," state the authors of an article
published in the July 2008 issue of Obstetrics and Gynecology.
Virtually all obstetricians who deliver neonates encounter perinatal
death. It is estimated that approximately 15% of pregnancies end in
early losses (before 20 weeks' gestation), and 1.3% end in either fetal
death (losses after 20 weeks but before delivery) or infant death
(deaths in the first year of life). It is well known that a perinatal
death has a significant effect on bereaved families, but little is
known about how client deaths in general affect physicians and
specifically about how fetal or infant deaths affect obstetricians. The
article presents findings from a study to identify U.S. obstetricians'
experiences with and attitudes about perinatal death, their coping
strategies, and their beliefs about the adequacy of their training on
this topic.
The researchers used simple random sampling to identify U.S.
obstetricians from the American Medical Association Physician
Masterfile confirmed to have an active U.S. license according to state
medical board Web sites. Each obstetrician received up to three mailed
copies of the four-page anonymous survey. The survey included questions
on personal experiences and beliefs about perinatal death and client
care, bereavement training and skills, and demographics. A total of 804
obstetricians completed the full survey, for a response rate of 54%.
The analyses examined obstetrician attributes associated with the
following outcome variables: whether fetal death takes a large
emotional toll on the obstetrician, whether the obstetrician had ever
considered giving up obstetrics due to the emotional toll of
stillbirths, belief that the obstetrician's own training was adequate
to cope with fetal or infant death, belief that health professionals in
general have adequate training to cope with fetal or infant death,
blaming self or feeling guilty when no cause of death is known, and
worrying about legal or disciplinary action when no cause of death is
known.
The authors found that
- When asked whether caring for clients with a current fetal death
took a large emotional toll on them personally, 22% of respondents
strongly agreed, and 53% agreed.
- Eight percent of respondents reported that they had considered
giving up obstetric practice because of the emotional difficulty of
caring for clients with a fetal death.
- Respondents who reported adequate training to cope with fetal and
infant death were significantly less likely to report having felt
guilty for a death without known cause.
- When asked to indicate all the measures they had used to cope
with their own emotions after a perinatal death, the two most common
methods reported were talking informally with colleagues (87%) and
talking about the death with friends or family (56%).
"Perinatal death takes a significant emotional toll on obstetricians,
and physician training offers an important opportunity to assist
physicians in coping when this traumatic experience occurs," conclude
the authors.
Gold KJ, Kuznia AL, Hayward RA. 2008. How physicians cope with
stillbirth or neonatal death. Obstetrics and Gynecology 112(1):29-34.
Abstract available at http://www.greenjournal.org/cgi/content/abstract/112/1/29.
Readers: More information is available from the NSIDRC's Professional
Resources Web page at http://www.sidscenter.org/ProfessionalResources.html.
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5. ARTICLE IDENTIFIES MATERNAL AND INFANT CHARACTERISTICS ASSOCIATED
WITH INFANT SLEEP POSITIONING
"We found several infant and maternal characteristics that may help
identify populations to be targeted for future sleep positioning
interventions," state the authors of an article published in the August
2008 issue of the Journal of Pediatrics. Since the early 1990s, prone
(stomach) sleep positioning has been a recognized risk factor for
sudden infant death syndrome (SIDS). In December 1996, new evidence
suggested that lateral (side) placement was associated with an
increased risk of SIDS, compared with supine (back) placement. The
American Academy of Pediatrics (AAP) task force 1992 recommendation
that infants be placed to sleep in the supine position (which was
updated in 1996 to state that the supine position is preferred over the
lateral position) is believed to be largely responsible for the 40%
reduction in the national incidence of SIDS that occurred between 1992
and 1997. The study described in this article aims to identify factors
predictive of either infant prone or lateral sleep positioning.
Study participants were mothers and their infants who took part in the
Pregnancy Risk Assessment (PRAMS) statewide population-based survey
between 1996 and 2000 in Washington State. PRAMS is an ongoing
behavioral survey developed by the Centers for Disease Control and
Prevention administered to a sample of new mothers in 37 states when
their infants are approximately 2 to 5 months old, when the risk of
SIDS is high. Since 1996, the survey has included the question "how do
you most often lay your baby down to sleep now?"
The authors found that
- There were 11,340 Washington State PRAMS survey respondents from
1996 to 2002 who answered the sleep position question as primarily
supine (7,029), prone (1,188), or lateral (3,123) and whose records
were linked to birth certificate and hospital discharge data; 65%
typically placed their infants to sleep in the supine position, 10.6%
in the prone position, and 24.1% in the lateral position.
- Dramatic changes in sleep positioning occurred in Washington
State over this period. The prevalence of supine positioning increased
by more than 30%; concomitantly, prone and lateral positioning declined
substantially.
- Maternal African-American race, being born in the United States,
primiparity, and earlier infant birth year were most predictive of
prone sleep positioning. Maternal residence outside the Seattle area
and infant male sex were also positively associated with prone sleep
positioning.
- The factors most highly predictive of lateral sleep positioning
were maternal nonwhite and non-Native American race, Medicaid payment
for delivery, infant's earlier birth year, and mother's county or
residence being other than the Seattle area. Other independent,
positive predictors included primiparity, mother's receipt of
government benefits during pregnancy, prematurity, and infant of normal
birthweight (vs low birthweight).
The authors conclude that "SIDS prevention efforts may benefit from
consideration of factors predicting either lateral or prone infant
sleep positioning."
McKinney CM, Holt VL, Cunningham ML, et al. 2008. Maternal and infant
characteristics associated with prone and lateral infant sleep
positioning in Washington State, 1996-2002. Journal of Pediatrics
153(2):194-198. Abstract available at http://www.jpeds.com/article/S0022-3476(08)00099-1/abstract.
Readers: More information is available from the NSIDRC's Safe Sleep
Environment Web page at http://www.sidscenter.org/SafeSleep/index.html.
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