
Maternal and Child Health Library
MCH Alert: Focus on Infant Mortality is developed by the Maternal
and Child Health Library in collaboration with the National Sudden
Infant Death Resource Center. This and past issues are available online
at http://www.mchlibrary.info/alert/archives.html
and http://www.sidscenter.org/alert/archives.html.
April 25, 2008
1. MCHB Announces Initial Release of Discretionary Grant
Web Reports
2. Report Presents Pregnancy Rates for 1990-2004
3. Authors Examine Correlation Between Cardiorespiratory
Events and Epidemiological Risk Factors for SIDS
4. Study Explores Effects of Crash Characteristics and
Maternal Restraint on Fetal Outcomes After Motor Vehicle Crashes
5. Research Findings Provide New Data on Which to Base
Decisions About Intensive Care for Extremely Premature Newborns
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1. MCHB ANNOUNCES INITIAL RELEASE OF DISCRETIONARY GRANT WEB REPORTS
The Discretionary Grant Information System (DGIS) Web reports display
financial, national performance measure, and abstract data collected
annually from more than 900 grants issued by the Health Resources and
Services Administration (HRSA), Maternal and Child Health Bureau
(MCHB), including data from grants to reduce disparities in infant
mortality. The public reports contain data collected by MCHB via a
Web-based system that allows grantees to report their data online as a
part of the grant-application and performance-reporting processes. Data
contained in the reports help MCHB assess the effectiveness of its
programs and help staff monitor the progress made under these grants.
The DGIS complements the existing Title V Information System (TVIS),
which electronically captures data from the annual Title V Block Grant
applications and reports submitted by all 59 U.S. states, territories,
and jurisdictions. The TVIS provides information on key measures and
indicators of maternal and child health (MCH) in the United States. The
DGIS and Title V reports are intended for use by public health
professionals, researchers, and the public in accessing concise
information about programs working to improve the quality of and access
to health care for MCH populations. Additional reports to be released
in the future will focus on other program and performance measure data.
The DGIS reports and the TVIS are available at http://www.mchb.hrsa.gov/data.
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2. REPORT PRESENTS PREGNANCY RATES FOR 1990-2004
"This report presents pregnancy rates . . . for women in age groups
10-14 through 40-44 years in the United States for the years 1990
through 2004," state the authors of an article published in the April
14, 2008, issue of National Vital Statistics Reports. Rates are
presented by pregnancy outcome; by age, race, and Hispanic origin; and
by marital status, race, and Hispanic origin. The data presented in
this report, together with previously published pregnancy rates for
earlier years, provide a consistent series of rates for the United
State for 1976-2004.
Statistics for live births are based on complete counts of births
provided by every state to the Centers for Disease Control and
Prevention's (CDC's) National Center for Health Statistics (NCHS)
through the Vital Statistics Cooperation Program of the National Vital
Statistics System. Estimates of induced abortions are from abortion
surveillance information collected from most states by CDC's National
Center for Chronic Disease Prevention and Health Promotion and national estimates
of abortion totals by the Guttmacher Institute. Estimates of fetal losses are
derived from the pregnancy history data collected by the National Survey of Family
Growth, conducted by CDC's NCHS.
The authors found that
- There were almost 6.4 million pregnancies in 2004 among women of
all ages, about 6% fewer than the nearly 6.8 million in 1990.
- Pregnancy rates for women under age 25, including teenagers,
declined in 2004 compared with 1990.
- Women ages 25-29 had the highest pregnancy rate, at 169 per
1,000, closely followed by women ages 20-24, at 164 per 1,000.
- The pregnancy rate for married women declined by 12% from 1990 to
1996-1997. From 1997 to 2000, the rate increased by about 5% and varied
little through 2004.
- The pregnancy rate for unmarried women declined continuously from
1990 to 1999, falling by 13%. The rate changed little through 2004.
- Pregnancy rates declined steadily for teenagers from 1990 to
2004, by 38% overall.
- More than two-thirds of pregnancies to non-Hispanic white women
(69%) and Hispanic women (67%) and half of pregnancies to non-Hispanic
black women ended in live birth.
- Pregnancy rates and birth rates were much higher at the younger
ages for black and Hispanic women than for white women, despite the
widespread declines in pregnancy rates at ages 15-24 from 1990 through
2003.
- Three out of four pregnancies (75%) among married women ended in
a live birth in 2004, while 19% ended in a fetal loss, and 6 percent
ended in abortion. For unmarried women, slightly over half of
pregnancies (51%) ended in a live birth, an increase from 43% in 1990.
Thirty-five percent of these pregnancies ended in abortion, and 13%
ended in fetal loss.
The authors conclude that "factors that are closely related to
pregnancy rates -- sexual activity, contraceptive use, and patterns of
marriage, divorce, and cohabitation -- are in turn affected by other
factors. These include: the level of effort toward, and the nature of,
programs focusing teenagers' attention on preventing pregnancy and
STDs; the number of children desired by men and women; the economic and
social environments in which people live; changes in access to health
care and health insurance; and other changes in the health care system,
including programs aimed toward reproductive health and family
planning."
Ventura SJ, Abma JC, Mosher WD, et al. 2008. Estimated pregnancy rates
by outcome for the United States, 1990-2004. National Vital Statistics
Reports 56(15):1-25. Available at http://www.cdc.gov/nchs/data/nvsr/nvsr56/nvsr56_15.pdf.
Readers: More information is available from the following MCH Library
resource:
- Knowledge Path: Preconception and Pregnancy at
http://www.mchlibrary.info/KnowledgePaths/kp_pregnancy.html
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3. AUTHORS EXAMINE CORRELATION BETWEEN CARDIORESPIRATORY EVENTS AND
EPIDEMIOLOGICAL RISK FACTORS FOR SIDS
"The duration of any event that marks entry into a danger zone that
will inevitably be followed by an infant's death remains to be
determined," state the authors of an article published in the May 2008
issue of the Journal of Pediatrics. The historical focus on apnea as
either a cause of sudden infant death (SIDS) or a mechanism of death
has decreased because studies have failed to implicate these events
directly. This article presents findings from a study to further
examine the role of apnea in the etiology of SIDS and the possibility
that either conventional events (apnea persisting for at least 20
seconds) or extreme events (apnea persisting for more than 30 seconds)
can predict imminent SIDS deaths.
Data were drawn from the Collaborative Home Infant Monitoring
Evaluation (CHIME), a study conducted during the 1990s for which
systematic home monitoring was performed on more than 1,000 infants in
five U.S. clinical centers. The present study included the
home-monitoring records of 306 healthy term infants; 170 siblings of
SIDS infants (SSIDS), 50 of whom were preterm; 152 infants with an
idiopathic apparent life-threatening event (ALTE), 45 of whom were
preterm; and 454 preterm infants. The analyses evaluated three
definitions of outcome events: (1) having at least one extreme event;
(2) having at least one conventional event without having an extreme
event; or (3) belonging to the half with the most events. In addition,
the researchers examined the presence of extra-long apneic periods (40
seconds or more). Because prematurity was found to be highly predictive
of having at least one extreme event in the original study, this
variable was always used as a covariate in the multivariate analyses.
Analyses were performed first for all infants and all events during the
entire monitoring period and then separately for the events occurring
before and at 44 weeks postmenstrual age (PMA) and those occurring
after 44 weeks PMA. (The highest risk for SIDS in preterm infants is
earlier and has a much wider dispersion.) The effect of time of night
on the incidence of events was established using repeated observations
for each subject. The relationship between extreme and conventional
events (i.e., the rate of decline as a function of maturity) was
examined as well.
The authors found that
- In the cohort 44 weeks or less PMA, the SSIDS, ALTE, and preterm
infants were at significantly increased risk for at least one extreme
event, compared with healthy term infants. However, the effect
disappeared after 43 weeks PMA (well before the peak incidence of SIDS).
- None of the SIDS risk factors were significantly related to
having at least one extreme event.
- Infants whose mothers smoked during pregnancy had significantly
fewer conventional events.
- Infants were less likely to have an extreme event in the early
morning hours (between 4:00 a.m. and 7:00 a.m., when infants tend to be
at higher risk of SIDS) than earlier in the night.
- The incidence of conventional events was higher between 10:00
p.m. and 1:00 a.m. and between 1:00 a.m. and 4:00 a.m. than between
4:00 a.m. and 7:00 a.m.
- Nineteen infants (1.8%) exhibited apneic episodes of 40 seconds
or longer.
"Neither extreme nor conventional events were associated with primary
epidemiologic risk factors for SIDS, supporting our hypothesis that
they are not immediate precursors of or causally related to SIDS,"
state the authors. They conclude that "conventional and extreme events
are probably normal, part of a continuum and not fundamentally
different in mechanism."
Hoppenbrouwers T, Hodgman JE, Ramanathan A, et al. 2008. Extreme and
conventional cardiorespiratory events and epidemiologic risk factors
for SIDS. Journal of Pediatrics 152(5):636-641. Abstract available at http://www.jpeds.com/article/S0022-3476(07)00959-6/abstract.
Readers: More information is available from the following MCH Library
resources:
- Knowledge Path: Infant Mortality at
http://www.mchlibrary.info/KnowledgePaths/kp_infmort.html
- Prematurity (bibliography) at
http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_premature.html&-MaxRecords=all&-DoScript=auto_search_premature&-search
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4. STUDY EXPLORES EFFECTS OF CRASH CHARACTERISTICS AND MATERNAL
RESTRAINT ON FETAL OUTCOMES AFTER MOTOR VEHICLE CRASHES
"This study shows that proper use of a belt restraint [during a motor
vehicle crash] by a pregnant occupant has a significant positive effect
on fetal outcome," state the authors of an article published in the
April 2008 issue of the American Journal of Obstetrics and Gynecology.
The public health problem of fetal loss and injury from maternal
involvement in motor vehicle crashes is difficult to quantify. Reliable
statistics on fetal loss resulting from automotive trauma are not
available because maternal involvement in crashes has not been
consistently recorded on fetal death certificates. In addition, the
pregnancy status of women involved in crashes has been tracked in
national databases only since 1995. The purpose of the study described
in this report was to conduct in-depth investigations of motor-vehicle
crashes involving pregnant occupants, with a focus on determining how
restraint conditions and specific crash characteristics affect fetal
outcome.
The authors investigated crashes involving 57 pregnant occupants.
Maternal and fetal injuries, restraint information, measures of
external and internal vehicle damage, and details about the crash
circumstances were collected. Crash severity was calculated using
vehicle crush measurements. Chi-square analysis and logistic regression
models were used to determine factors with a significant association
with fetal outcome.
The authors found that
- Fetal outcome is significantly associated with crash severity,
such that minor crashes are more likely to result in acceptable fetal
outcomes, whereas severe crashes are more likely to produce adverse
fetal outcomes.
- Fetal outcome is strongly associated with severity of maternal
injury, with more serious fetal outcomes associated with more severe
maternal injury.
- An 84% reduction in risk of adverse fetal outcome is obtained if
the pregnant occupant properly wears a seatbelt.
The authors conclude that "the results of this study support the
current recommendation that pregnant women should properly wear 3-point
seatbelts."
DeSantich Klinich K, Flannagan CAC, Rupp JD, et al. 2008. Fetal outcome
in motor-vehicle crashes: effects of crash characteristics and maternal
restraint. American Journal of Obstetrics and Gynecology
198(4):450.e1-450.e.9. Full-text available at http://www.ajog.org/article/S0002-9378(08)00145-2/fulltext.
Readers: More information is available from the following MCH Library
resource:
- Injury Prevention (organizations resource list) at
http://www.mchlibrary.info/action.lasso?-database=Organizations&-layout=Web&-response=/databases/OrgLists/orgs_injury.html&-MaxRecords=all&-DoScript=auto_search_injury&-search
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5. RESEARCH FINDINGS PROVIDE NEW DATA ON WHICH TO BASE DECISIONS ABOUT
INTENSIVE CARE FOR EXTREMELY PREMATURE NEWBORNS
"Our findings challenge the widespread use of gestational-age
thresholds alone deciding whether to administer intensive care to
extremely premature infants," state the authors of an article published
in the April 17, 2008, issue of the New England Journal of Medicine.
The evidence base providing support for decisions to initiate or forgo
intensive care for extremely premature infants is limited, and the
measurement error in assessing pregnancy length may prompt different
treatment decisions. The article presents findings from a study
designed to better inform such decisions. The study assessed a large
cohort of infants born at 22 to 25 weeks' gestation in the Neonatal
Research Network (NRN) of the National Institute of Child Health and
Human Development and related gestational age and other risk factors
assessable at or before birth to the likelihood of death or adverse
neurodevelopmental outcomes.
The study sample included 4,446 infants born at 22 to 25 completed
weeks of gestation in 19 NRN centers between January 1, 1998, and
December 31, 2003. Researchers estimated the percentages of infants
with the following pre-specified primary outcomes: survival, survival
without impairment, and survival without profound impairment (based on
standardized neurodevelopmental assessments performed at a corrected
age of 18 to 22 months). Each outcome was then analyzed for infants who
received intensive care. (The researchers considered intensive care to
have been provided if mechanical ventilation was initiated.) All
infants who underwent ventilation were categorized into risk groups
according to birthweight, sex, exposure or nonexposure to antenatal
corticosteroids, and single or multiple births. (Analyses found race or
ethnic group and the type of delivery to be unrelated to the three
outcomes.) For each group, the percentage of infants with an
unfavorable outcome was predicted with the use of gestational age alone
and according to multiple risk factors. The observed and estimated
rates were then compared.
The authors found that
- At 18 to 22 months, 49% of the study infants had died, 61% had
died or had profound impairment, and 73% had died or had impairment.
- Increased birthweight, female sex, any use of antenatal
corticosteroids, and singleton birth were each associated with
reductions in risks of death and of death or profound or any
neurodevelopmental impairment; these reductions were similar to those
associated with a 1-week increase in gestational age.
- At the same estimated likelihood of a favorable outcome, the
likelihood of receiving intensive care was lower for girls than for
boys and for singletons than for multiples.
- The outcomes of the infant risk groups were predicted more
accurately with the use of five factors (gestational age, birthweight,
sex, exposure or nonexposure to antenatal corticosteroids, and single
or multiple gestation) than with the use of gestational age alone.
The authors conclude that "consideration of multiple factors is likely
to promote treatment decisions that are less arbitrary, more
individualized, more transparent, and better justified than decisions
based solely on gestational-age thresholds."
Tyson JE, Parikh NA, Langer J, et al. April 17, 2008. Intensive care
for extreme prematurity: Moving beyond gestational age. New England
Journal of Medicine 258(16):1672-1681. Full-text available at http://content.nejm.org/cgi/content/full/358/16/1672?query=TOC.
Readers: The NRN Web site contains a tool that clinicians can use to
estimate the likelihood that intensive care will benefit individual
infants (after considering the extent to which outcomes might differ
from those identified by the NRN). The tool is available at http://www.nichd.nih.gov/neonatalestimates.
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MCH Alert © 1998-2008 by National Center for Education in Maternal
and
Child Health and Georgetown University. MCH Alert: Focus on Infant
Mortality is produced by
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