
Maternal and Child Health Library
MCH Alert: Focus on Infant Mortality is developed by the Maternal
and Child Health Library in collaboration with the National Sudden
Infant Death Resource Center. This and past issues are available online
at http://www.mchlibrary.info/alert/archives.html
and http://www.sidscenter.org/alert/archives.html.
March 28, 2008
1. Documentary Series Examines Infant Mortality Within
the Context of Racial and Socioeconomic Inequalities
2. Resource Incorporates Evolving Understanding of the
Nature and Etiology of Disparities
3. Study Examines Whether Differences in Hospitals Where
Infants are Born Contribute to Disparities
4. Review Summarizes Literature on Grief Subsequent to an
Early Miscarriage
5. Article Assesses Relationship Between Maternal
Caffeine Intake and Miscarriage Risk
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Special Notice: Training Course in Maternal and Child Health
Epidemiology is a national program designed to build conceptual,
technical, and analytic skills among professionals who have significant
responsibility for collecting, processing, analyzing, and reporting
maternal and child health data. The course will be held on June 2-7,
2008, in Chicago, Illinois, and is sponsored by the Health Resources
and Services Administration's Maternal and Child Health Bureau (MCHB)
and the Centers for Disease Control and Prevention as part of their
ongoing effort to enhance the analytic capacity of state and local
health agencies. The application form (due April 7, 2008) is available
at http://www.positiveoutcomes.net/mchb_epi/MCHB_Epidemiology_Training_Course.doc.
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1. DOCUMENTARY SERIES EXAMINES INFANT MORTALITY WITHIN THE CONTEXT
OF RACIAL AND SOCIOECONOMIC INEQUALITIES
Unnatural Causes: Is Inequality Making Us Sick? is a seven-part
documentary series that explores ways in which social conditions affect
population health and how some communities are extending lives by
improving these conditions. Conceived as part of a larger impact
campaign in association with leading public health, policy, and
community-based organizations, the series is a production of California
Newsreel with Vital Pictures. Episode 2 in the series, titled When the
Bough Breaks, specifically examines the conditions that surround and
negatively impact African-American women and their infants. Information
about the documentary series and series objectives, episode
descriptions, video clips, a discussion guide, and transcripts are
available from the series' Web site. A searchable database containing
articles, Web sites, data, interviews, interactivities, case studies,
and educational and outreach materials is also provided. More
information is available at http://www.unnaturalcauses.org.
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2. RESOURCE INCORPORATES EVOLVING UNDERSTANDING OF THE NATURE AND
ETIOLOGY OF DISPARITIES
Racial and Ethnic Disparities in U.S. Health Care: A Chartbook offers a
set of data and discussion intended to help policymakers, teachers,
researchers, and practitioners begin to understand disparities in their
communities and to formulate solutions. The chartbook, published by the
Commonwealth Fund, is divided into seven chapters. Topics include
changes in the U.S. population by race and ethnicity, income, and
language; disparities in a number of the focus areas of the Healthy
People 2010 initiative; the challenges minority Americans face in
receiving needed health care (including both primary and specialized
care); why insurance coverage varies by race and ethnicity; existing
racial and ethnic disparities across the domains of quality articulated
by the Institute of Medicine; and strategies that may lessen or
eliminate disparities in health and health care. Data, including infant
mortality data, are presented in charts throughout the document.
Explanatory notes about the data in the charts are provided. The
chartbook is available at http://www.commonwealthfund.org/usr_doc/Mead_racialethnicdisparities_chartbook_1111.pdf?section=4039.
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3. STUDY EXAMINES WHETHER DIFFERENCES IN HOSPITALS WHERE INFANTS
ARE BORN CONTRIBUTE TO DISPARITIES
"Black VLBW [very low birthweight] infants are more likely to be born
in New York City hospitals with higher risk-adjusted neonatal mortality
rates than are white VLBW infants," state the authors of an article
published in the March 2008 issue of Pediatrics. This article presents
findings from a study to investigate the association of hospital
neonatal deaths (deaths within 28 days after delivery) and race.
Specifically, the researchers sought to determine whether black VLBW
infants are born in hospitals with the same mortality rates for VLBW
infants as are white VLBW infants.
Data were obtained from New York City vital statistics birth and death
files. Death files from January 1, 1996, through January 31, 2002, were
linked to birth certificate data from January 1, 1996, through December
31, 2001. All live VLBW births (defined as birthweights of less than
1,500 g and greater than 499 g) that occurred in hospitals in the five
boroughs of New York City were included (N=11,781). The researchers
calculated risk-adjusted VLBW neonatal mortality rates (non-Hispanic
black vs. non-Hispanic white) with and without hospital-level variables.
The authors found that
- Risk-adjusted mortality rates according to hospital ranged from
9.6% to 27.2%.
- Forty-nine percent of all white VLBW births occurred in the
lowest mortality tertile of hospitals, compared with 29% of all black
VLBW births. If black VLBW infants had been born in the same
proportions in the same hospitals as white VLBW infants, then the
estimated mortality rate for black infants would decrease by 4.8%, to
132.3 deaths per 1,000 VLBW births, reducing the black/white disparity
in VLBW neonatal mortality rates in New York City by 34.5%.
- If black VLBW infants were born at high-volume hospitals at the
same percentage as white VLBW infants, then the estimated mortality
rate for black VLBW infants would be 137.1 deaths per 1,000 VLBW
births, which represents a 1.4% decrease in mortality rates for black
VLBW infants, and the black/white mortality rate disparity would
decrease by 10%.
"The finding that, in New York City, black infants who are born too
small systematically receive care in institutions with worse outcomes,
compared with those where white infants receive care, demands immediate
attention," state the authors. They conclude that "improving outcomes
at the lowest-performing hospitals may produce the greatest benefit."
Howell EA, Hebert P, Chatterjee S, et al. 2008. Black/white differences
in very low birth weight neonatal mortality rates among New York City
hospitals. Pediatrics 121(3):e407-e415. Abstract available at http://pediatrics.aappublications.org/cgi/content/abstract/121/3/e407?rss=1.
Readers: More information is available from the following MCH Library
resources:
- Knowledge Path: Infant Mortality at
http://www.mchlibrary.info/KnowledgePaths/kp_infmort.html
- Knowledge Path: Racial and Ethnic Disparities in Health at
http://www.mchlibrary.info/KnowledgePaths/kp_race.html
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4. REVIEW SUMMARIZES LITERATURE ON GRIEF SUBSEQUENT TO AN EARLY
MISCARRIAGE
"The paucity of clear information as to the incidence, characteristics,
and duration of grief following miscarriage suggests that practitioners
can offer only suggestive guidelines as to what constitutes an adaptive
or typical reaction to miscarriage," states the author of an article
published in the March 2008 issue of the Journal of Women's Health.
Although there is increasing acceptance that a miscarriage represents a
significant loss experience, the empirical literature on grief
following miscarriage remains limited. This article presents findings
from a literature review on grief following miscarriage. The purpose of
the review was to elucidate the nature of grief following an early
miscarriage (before the 20th week of gestation); to determine the
incidence, intensity, and duration of grief at this time; and to
identify the variables that potentially moderate its intensity and
duration.
The author conducted a search of Medline and Psych Info databases
covering the period from January 1966 through January 2007 using the
keywords miscarriage, spontaneous abortion, pregnancy loss in
combination with grief, mourning, and bereavement. Further searches
were then carried out using references cited in the identified papers.
Studies were subsequently included in the review if the majority of
women in a study sample experienced an early miscarriage, a
standardized measure of perinatal grief was used, and assessment
intervals were clearly specified.
The author found that
- The affective and behavioral reactions that typically occur
following miscarriage seem similar to the affective and behavioral
reactions that typically occur following other types of significant
loss. At the same time, grief following miscarriage seems somewhat
distinct from grief that typically occurs following other losses in the
preponderant emphasis on times ahead rather than on remembered times.
- With regard to the percentage of individuals who experience a
grief reaction following miscarriage, no clear guidelines can be
formulated. The available literature does suggest that grief reactions
are common and that the grief is similar in intensity to grief
following other types of losses. In addition, like grief following
other types of losses, grief after miscarriage seems to abate in
intensity by about 6 months following the miscarriage.
- Gender differences in relation to grief following miscarriage are
evident, with men seeming to experience less intense and enduring grief
than women.
- Although many variables have been studied to determine their role
as moderators of the intensity and duration of grief following
miscarriage, few clear conclusions can be drawn.
The authors conclude that "the similarity in the results of studies
examining the duration and intensity of grief following miscarriage and
the duration and intensity of grief following other types of losses
supports using the general literature on grief to help guide patient
expectations."
Brier N. 2008. Grief following miscarriage: A comprehensive review of
the literature. Journal of Women's Health ahead of print. Abstract
available at http://www.liebertonline.com/doi/abs/10.1089/jwh.2007.0505.
Readers: More information is available from the following MCH Library
resource:
- Prenatal Care (bibliography) at
http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_prenatal.html&-MaxRecords=all&-DoScript=auto_search_prenatal&-search
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5. ARTICLE ASSESSES RELATIONSHIP BETWEEN MATERNAL CAFFEINE INTAKE AND
MISCARRIAGE RISK
"The results from our prospective cohort study supported previous
findings that high caffeine consumption during pregnancy may increase
the risk of miscarriage," write the authors of an article published in
the March 2008 issue of the American Journal of Obstetrics and
Gynecology. Caffeine is among the most frequently ingested
pharmacologically active substances in the world. Caffeine can readily
cross the placental barrier to the fetus and has been reported to
increase the risk of miscarriage. However, the effect of caffeine on
the risk of miscarriage remains controversial because of methodological
limitations in past studies. The objective of the present
population-based prospective study was to examine the effect of
maternal caffeine intake during pregnancy on the risk of miscarriage,
taking into account a number of potential confounders, especially the
impact of nausea and vomiting during pregnancy.
Study participants consisted of 1,185 women who resided in the San
Francisco and South San Francisco areas and who were members of the
Kaiser Permanente Medical Care Program (KPMCP). Participants had a
positive pregnancy test during the 2-year period from October 1996 to
October 1998. Information on exposure to caffeine was obtained during
an in-person interview conducted soon after a woman's pregnancy was
confirmed. Information on potential confounders, such as maternal age,
race, education, household income, marital status, smoking, alcohol
consumption, Jacuzzi use, exposure to magnetic fields (MF) during
pregnancy, and symptoms related to pregnancy such as nausea and
vomiting were also collected during the in-person interview.
The authors found that
- Overall, 172 women (16.18%) miscarried.
- Whereas 264 women (25%) reported no caffeine consumption during
pregnancy, 635 women (60%) reported 0-200 mg of caffeine consumption
per day, and 164 women (15%) reported 200 mg or more of caffeine
consumption per day.
- Compared with non-users, women who consumed 0-200 mg of caffeine
per day had an increased risk of miscarriage (15% vs. 12%), and the
corresponding risk was much greater (25%) among women who consumed 200
mg or more per day.
- After adjusting for potential confounders, including maternal
age, race, education, household income, marital status, previous
miscarriage, smoking, alcohol consumption, Jacuzzi use, MF exposure,
and nausea and vomiting, the hazard ratio of miscarriage was 1.42 and
2.23 for daily caffeine consumption of 0-200 mg and 200 mg or more,
respectively.
- Caffeine's affect on the risk of miscarriage remained strong
among women without a history of miscarriage, whereas the association
no longer existed among women with such a history.
The authors conclude that "it may be prudent to stop or reduce caffeine
intake during pregnancy."
Weng X, Odouli R, Li D. 2008. Maternal caffeine consumption during
pregnancy and the risk of miscarriage: a prospective cohort study.
American Journal of Obstetrics and Gynecology 198(3):279.e1-278.e8.
Available at http://www.ajog.org/article/S0002-9378(07)02025-X/fulltext.
Readers: More information is available from the following MCH Library
resources:
- Substance Use During Pregnancy (bibliography) at
http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_subusepreg.html&-MaxRecords=all&-DoScript=auto_search_subusepreg&-search
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MCH Alert © 1998-2008 by National Center for Education in Maternal
and
Child Health and Georgetown University. MCH Alert: Focus on Infant
Mortality is produced by
Maternal and Child Health Library at the National Center for Education
in Maternal and Child Health under its cooperative agreements
(U02MC00001 and U48MC08717) with the Maternal and Child Health Bureau,
Health
Resources and Services Administration, U.S. Department of Health and
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MCH Alert
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