
Maternal and Child Health Library
This and past issues of the MCH Alert are available at http://www.mchlibrary.info/alert/archives.html.
April 20, 2007
1. Report Highlights Progress Toward Meeting Healthy
People 2010 Maternal, Infant, and Child Health Objectives
2. Guide Updated for Cover the Uninsured Week
3. Authors Examine Mental Disorders and Nicotine
Dependence Among Pregnant Women
4. Article Presents Findings on the Impact of Suicidality
Data on Physician Practice Patterns
5. Article Examines Changing Patterns of Inequalities in
U.S. Infant, Neonatal, and Postneonatal Mortality Rates
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Special Notice: The impact on young people and families of this week’s
events at the Virginia Tech campus presents many challenges to
educators, health professionals, and others. Our hearts go out to all
people affected. Over the next several days, there will undoubtedly be
a great deal of media coverage about this event. Young people may
have
questions or relay fears regarding their safety. Information is
available from Bright Futures in Practice: Mental Health at http://www.brightfutures.org/mentalhealth/index.html,
from What to Expect and When to Seek Help at http://www.brightfutures.org/tools/index.html,
and from the MCH Library's resource guide, Reaching Out to Children and
Youth Following Disasters: Selected Resources at http://www.mchlibrary.info/inforeviews/reachingout.html.
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1. REPORT HIGHLIGHTS PROGRESS TOWARD MEETING HEALTHY PEOPLE 2010
MATERNAL, INFANT, AND CHILD HEALTH OBJECTIVES
Healthy People 2010 Midcourse Review: Maternal, Infant and Child Health
highlights results from an assessment of progress toward achieving the
Healthy People (HP) 2010 maternal, infant, and child health goals and
objectives through the first half of the decade. The purpose of the
midcourse review, which was led by the Centers for Disease Control and
Prevention and the Health Resources and Services Administration, is to
assess data trends; consider new science and available data; and, if
appropriate, revise the objectives to ensure that HP 2010 remains
current, accurate, and relevant to public health priorities. Topics
include modifications to objectives and sub-objectives, progress toward
Healthy People 2010 targets, progress toward elimination of health
disparities, opportunities and challenges, and emerging issues.
References and related objectives from other focus areas are also
included. The report is available at http://www.healthypeople.gov/data/midcourse/pdf/FA16.pdf.
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2. GUIDE UPDATED FOR COVER THE UNINSURED WEEK
Health Care Coverage in America: Understanding the Issues and Proposed
Solutions provides an overview of how Americans get health coverage,
why so many don't have coverage, and what could be done to ease the
problem. The 24-page guide, updated for Cover the Uninsured Week (April
23-29, 2007), was prepared by the Alliance for Health Reform with
support from the Robert Wood Johnson Foundation. Graphs, a glossary of
health-coverage terms, and links to sources of additional information
are included. The guide is available at http://www.allhealth.org/publications/Uninsured/Health_Care_Coverage_in_America_2007_54.pdf.
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3. AUTHORS EXAMINE MENTAL DISORDERS AND NICOTINE DEPENDENCE AMONG
PREGNANT WOMEN
"These data suggest that cigarette use and nicotine dependence are not
uncommon among women who are pregnant in the United States, with more
than one in four pregnant women using cigarettes during pregnancy, and
approximately one in ten having a diagnosis of nicotine dependence,"
state the authors of an article published in the April 2007 issue of
Obstetrics and Gynecology. Evidence suggests that prenatal smoking most
commonly occurs among vulnerable populations; however, little
information is available beyond demographic correlates. The article
describes findings from a study based on previous findings of links
between mental disorders and nicotine dependence among adults. The
researchers estimated the prevalence of mental disorders among U.S.
women who smoke cigarettes or who have nicotine dependence during
pregnancy compared with those who do not smoke cigarettes or have
nicotine dependence. They then examined the degree to which the
association between mental disorders and cigarette smoking and nicotine
dependence is explained by differences in demographic characteristics
as well as by the co-morbidity of more than one mood, anxiety,
substance use, or personality disorder.
The study sample was drawn from the 2001-2002 National Epidemiologic
Survey of Alcohol and Related Conditions, a nationally representative,
cross-sectional survey of 43,093 adults (ages 18 and older). The
present analysis included only women reporting pregnancy in the past
year (N=1,517). The survey collected information on nicotine use and
dependence, seven mood and anxiety disorders (as defined by the
Diagnostic and Statistical Manual of Mental Disorders), and eight
personality disorders. The time frame for all diagnoses was the
preceding 12-month period. The researchers first calculated the
prevalence of specific mental disorders among women who were pregnant
and smoked cigarettes (both those who were nicotine dependent and those
who were not) and then determined the likelihood that a woman smoked
cigarettes or had nicotine dependence if she had been diagnosed with a
current mental disorder. Analyses were subsequently controlled for
race, location (central city, not central city), marital status,
education, and children (one or more, none). In the final analyses, the
researchers adjusted for any mental disorder other than that which was
the main predictor.
The authors found that
- Among pregnant women in the United States, 21.7% reported that
they smoked cigarettes and 12.4% met criteria for nicotine dependence.
- Among pregnant women who smoked cigarettes, 45.1% met criteria
for at least one mental disorder; among pregnant women with nicotine
dependence, 57.5% met criteria for at least one mental disorder.
- After adjustment for differences in demographic characteristics
and co-morbid mental disorders, the associations between major
depressive disorder, dysthymia, and panic disorder remained
significantly associated with nicotine dependence among pregnant women.
"Results suggest an urgent need for smoking cessation and nicotine
dependence treatment and that mental health outreach programs might be
indicated in conjunction with prenatal care, especially in underserved
areas," conclude the authors.
Goodwin RD, Keyes K, Simuro N. 2007. Mental disorders and nicotine
dependence among pregnant women in the United States. Obstetrics and
Gynecology 109(4):875-883. Abstract available at http://www.greenjournal.org/cgi/content/abstract/109/4/875.
Readers: More information is available from the MCH Library's
bibliographies, Smoking During Pregnancy, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_smokingpreg.html&-MaxRecords=all&-DoScript=auto_search_smokingpreg&-search
and Smoking and Tobacco Use Prevention, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_smokingprev.html&-MaxRecords=all&-DoScript=auto_search_smokingprev&-search.
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4. ARTICLE PRESENTS FINDINGS ON THE IMPACT OF SUICIDALITY DATA ON
PHYSICIAN PRACTICE PATTERNS
"The level of effect on antidepressant prescribing volume observed in
our analysis supports the findings reported . . . , suggesting that the
number of children and teenagers prescribed antidepressants has
decreased dramatically since the October 2003 and March 2004 FDA-issued
public health advisories that reported risks of suicidality with the
use of antidepressants," state the authors of an article published in
the April 2007 issue of the Archives of General Psychiatry. In October
2003, the U.S. Food and Drug Administration (FDA) issued a public
health advisory to call attention to reports of the occurrence of
suicidality in clinical trials for antidepressants in children and
adolescents with depression. In March 2004, the FDA issued a second
advisory asking manufacturers to include a warning statement in product
labeling that recommends monitoring of adult and pediatric patients for
the emergence of suicidality. The authors of the article discuss recent
data on the number of children and adolescents prescribed
antidepressants (these data indicate that the number has decreased) and
provide additional insight into the impact of the pediatric suicidality
findings on physician practice patterns.
Data for the analysis were obtained from Verispan, a data set
containing prescriptions from a variety of retail channels from a near
census of U.S. pharmacies, including information from all payer types
(private payer, Medicaid, cash). Focusing on the June 2000 to March
2005 time frame, the researchers tested for significance among observed
prescription trends by determining the average monthly percentage
change in antidepressant prescribing. Total antidepressant
prescriptions were analyzed as a moving quarterly total (a time series
aggregate over a 3-month period). A "suicide index" was created to
normalize for the differences in prescription volume between
individuals ages 18 and younger, those ages 18-25, and those ages 26
and older. To further explore the effect of the reported suicidality
data on practice patterns, the researchers also examined data from
Verispan's Physician Drug and Diagnosis Audit, a national-level disease
and treatment database of approximately 3,400 office-based physicians
across 29 specialties. The data were analyzed to better understand
changes in specialty physician treatment of children and adolescents
(ages 18 and younger) for depression and the antidepressants prescribed.
The authors found that
- The number of prescriptions for the ages-18-and-younger group
increased by a monthly average of 0.79% from April 2002 to February
2004. After February 2004, there was a decrease in the number of
prescriptions by a monthly average of 4.23%. By July 2004, the market
began to stabilize such that there was no significant change in
prescribing trends from July 2004 to March 2005.
- In quarter February 2004, psychiatrists cared for 44% of the
ages-18-and-younger group. In contrast, psychiatrists cared for 63% of
this group in quarter February 2005.
- There was an increase in prescribing of non-FDA-approved
antidepressants to the ages-18-and-younger group that was not observed
in the ages-18-and-older groups.
The authors conclude that "there is need for additional exploration
into the relationship between FDA action, media reaction, and physician
behavior change to ensure that dissemination of drug safety information
does not interfere with appropriate access to care."
Nemeroff C, Kalali A, Keller, M, et al. 2007. Impact of publicity
concerning pediatric suicidality data on physician practice patterns in
the United States. Archives of General Psychiatry 64(4):466-472.
Abstract available at http://archpsyc.ama-assn.org/cgi/content/short/64/4/466.
Readers: More information is available from Bright Futures in Practice:
Mental Health at http://www.brightfutures.org/mentalhealth/index.html
and What to Expect and When to Seek Help at http://www.brightfutures.org/tools/index.html;
and from the MCH Library's knowledge path, Mental Health in Children
and Adolescents, at http://www.mchlibrary.info/KnowledgePaths/kp_mentalhealth.html
and bibliographies, Adolescent Mental Health, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_adolmenhlth.html&-MaxRecords=all&-DoScript=auto_search_adolmenhlth&-search,
Children's Mental Health, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_chldmenhlth.html&-MaxRecords=all&-DoScript=auto_search_chldmenhlth&-search,
and Mental Health in Primary Care, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_mental.html&-MaxRecords=all&-DoScript=auto_search_mental&-search.
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5. ARTICLE EXAMINES CHANGING PATTERNS OF INEQUALITIES IN U.S. INFANT,
NEONATAL, AND POSTNEONATAL MORTALITY RATES
"The success in reducing absolute disparities in infant mortality must
be weighed against changes in the relative measures of disparity, which
are particularly important for assessing the progress of various social
groups relative to the best-off group toward reaching a health policy
goal, such as the elimination of health disparities," write the authors
of an article published in the April 2007 issue of Pediatrics
Electronic Pages. Infant mortality rates have declined dramatically in
the United States over the past 6 decades, yet racial, ethnic, and
social class disparities in infant mortality remain marked. Although
trends in health inequalities by race and ethnicity, gender, and
geographical area are analyzed routinely in the United States, the
analysis of changes in the extent of health inequalities over time
according to socioeconomic characteristics is far less common. The aim
of this article is to examine changes in the extent of inequalities in
U.S. infant, neonatal, and postnatal mortality rates between 1969 and
2001 by area of socioeconomic deprivation and maternal education.
The authors analyzed temporal inequalities in infant mortality by
linking county-level socioeconomic status (SES) data with birth and
death data from the National Vital Statistics System to derive annual
infant mortality rates from 1969 to 2000. To estimate SES trends at the
individual level, the authors computed infant mortality rates by
maternal education using national linked birth and death files.
The authors found that
- Infant mortality rates declined during the study period for all
the deprivation groups.
- Between 1969 and 1984, both absolute and relative socioeconomic
disparities in infant, neonatal, and postnatal mortality declined.
Beginning with the 1985-1989 period, however, the risk ratios (RRs) of
infant, neonatal, and postnatal mortality associated with area
deprivation generally increased.
- In 1985-1989, infants in the most deprived group had,
respectively, 36% and 57% higher risks of neonatal and postneonatal
mortality than infants in the least deprived group. In 1995-2000, the
deprivation gradient in infant mortality widened considerably, with
infants in the most deprived group experiencing 43% and 96% higher RRs
of neonatal and postnatal mortality, respectively, than their
least-deprived counterparts.
- Between 1986 and 2001, all maternal-education groups showed
substantial declines in mortality rates, but the adjusted relative
educational disparities were greater in 2001 than in 1986.
- Infant, neonatal, and postnatal mortality rates show dramatic
declines between 1986 and 2001 for the three birthweight strata
(very-low birthweight, moderately low birthweight, and normal
birthweight). The rate of decline in neonatal mortality during
1986-2001, however, was greater in all three strata in the highest
educational category than in the lower educational categories.
The authors conclude that "it will be a formidable challenge to meet
the 2010 target of 4.5 deaths per 1,000 live births, particularly for
infants in the most disadvantaged SES groups, of which the mortality
rates would have to be reduced by 50% during this decade."
Singh GP, Kogan, MD. 2007. Persistent socioeconomic disparities in
infant, neonatal, and postneonatal mortality rates in the United
States, 1969-2001. Pediatrics Electronic Pages 119(4):e928-e939.
Abstract available at http://pediatrics.aappublications.org/cgi/content/abstract/119/4/e928.
Readers: More information is available from the MCH Library's knowledge
path, Infant Mortality, at http://www.mchlibrary.info/KnowledgePaths/kp_infmort.html,
bibliography, Infant Mortality, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_infmortality.html&-MaxRecords=all&-DoScript=auto_search_infmortality&-search,
and organizations resource list, Infant Mortality Prevention, at http://www.mchlibrary.info/action.lasso?-database=Organizations&-layout=Web&-response=/databases/OrgLists/orgs_infmort.html&-MaxRecords=all&-DoScript=auto_search_infmort&-search.
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MCH Alert © 1998-2007 by National Center for Education in Maternal
and
Child Health and Georgetown University. MCH Alert is produced by
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