MCH Alert


Maternal and Child Health Library

This and past issues of the MCH Alert are available at http://www.mchlibrary.info/alert/archives.html.


April 20, 2007

1. Report Highlights Progress Toward Meeting Healthy People 2010 Maternal, Infant, and Child Health Objectives
2. Guide Updated for Cover the Uninsured Week
3. Authors Examine Mental Disorders and Nicotine Dependence Among Pregnant Women
4. Article Presents Findings on the Impact of Suicidality Data on Physician Practice Patterns
5. Article Examines Changing Patterns of Inequalities in U.S. Infant, Neonatal, and Postneonatal Mortality Rates

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Special Notice: The impact on young people and families of this week’s events at the Virginia Tech campus presents many challenges to educators, health professionals, and others. Our hearts go out to all people affected. Over the next several days, there will undoubtedly be a great deal of media coverage about this event.  Young people may have questions or relay fears regarding their safety. Information is available from Bright Futures in Practice: Mental Health at http://www.brightfutures.org/mentalhealth/index.html, from What to Expect and When to Seek Help at http://www.brightfutures.org/tools/index.html, and from the MCH Library's resource guide, Reaching Out to Children and Youth Following Disasters: Selected Resources at http://www.mchlibrary.info/inforeviews/reachingout.html.

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1. REPORT HIGHLIGHTS PROGRESS TOWARD MEETING HEALTHY PEOPLE 2010 MATERNAL, INFANT, AND CHILD HEALTH OBJECTIVES

Healthy People 2010 Midcourse Review: Maternal, Infant and Child Health highlights results from an assessment of progress toward achieving the Healthy People (HP) 2010 maternal, infant, and child health goals and objectives through the first half of the decade. The purpose of the midcourse review, which was led by the Centers for Disease Control and Prevention and the Health Resources and Services Administration, is to assess data trends; consider new science and available data; and, if appropriate, revise the objectives to ensure that HP 2010 remains current, accurate, and relevant to public health priorities. Topics include modifications to objectives and sub-objectives, progress toward Healthy People 2010 targets, progress toward elimination of health disparities, opportunities and challenges, and emerging issues. References and related objectives from other focus areas are also included. The report is available at http://www.healthypeople.gov/data/midcourse/pdf/FA16.pdf.

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2. GUIDE UPDATED FOR COVER THE UNINSURED WEEK

Health Care Coverage in America: Understanding the Issues and Proposed Solutions provides an overview of how Americans get health coverage, why so many don't have coverage, and what could be done to ease the problem. The 24-page guide, updated for Cover the Uninsured Week (April 23-29, 2007), was prepared by the Alliance for Health Reform with support from the Robert Wood Johnson Foundation. Graphs, a glossary of health-coverage terms, and links to sources of additional information are included. The guide is available at http://www.allhealth.org/publications/Uninsured/Health_Care_Coverage_in_America_2007_54.pdf.

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3. AUTHORS EXAMINE MENTAL DISORDERS AND NICOTINE DEPENDENCE AMONG PREGNANT WOMEN

"These data suggest that cigarette use and nicotine dependence are not uncommon among women who are pregnant in the United States, with more than one in four pregnant women using cigarettes during pregnancy, and approximately one in ten having a diagnosis of nicotine dependence," state the authors of an article published in the April 2007 issue of Obstetrics and Gynecology. Evidence suggests that prenatal smoking most commonly occurs among vulnerable populations; however, little information is available beyond demographic correlates. The article describes findings from a study based on previous findings of links between mental disorders and nicotine dependence among adults. The researchers estimated the prevalence of mental disorders among U.S. women who smoke cigarettes or who have nicotine dependence during pregnancy compared with those who do not smoke cigarettes or have nicotine dependence. They then examined the degree to which the association between mental disorders and cigarette smoking and nicotine dependence is explained by differences in demographic characteristics as well as by the co-morbidity of more than one mood, anxiety, substance use, or personality disorder.

The study sample was drawn from the 2001-2002 National Epidemiologic Survey of Alcohol and Related Conditions, a nationally representative, cross-sectional survey of 43,093 adults (ages 18 and older). The present analysis included only women reporting pregnancy in the past year (N=1,517). The survey collected information on nicotine use and dependence, seven mood and anxiety disorders (as defined by the Diagnostic and Statistical Manual of Mental Disorders), and eight personality disorders. The time frame for all diagnoses was the preceding 12-month period. The researchers first calculated the prevalence of specific mental disorders among women who were pregnant and smoked cigarettes (both those who were nicotine dependent and those who were not) and then determined the likelihood that a woman smoked cigarettes or had nicotine dependence if she had been diagnosed with a current mental disorder. Analyses were subsequently controlled for race, location (central city, not central city), marital status, education, and children (one or more, none). In the final analyses, the researchers adjusted for any mental disorder other than that which was the main predictor.

The authors found that
"Results suggest an urgent need for smoking cessation and nicotine dependence treatment and that mental health outreach programs might be indicated in conjunction with prenatal care, especially in underserved areas," conclude the authors.

Goodwin RD, Keyes K, Simuro N. 2007. Mental disorders and nicotine dependence among pregnant women in the United States. Obstetrics and Gynecology 109(4):875-883. Abstract available at http://www.greenjournal.org/cgi/content/abstract/109/4/875.

Readers: More information is available from the MCH Library's bibliographies, Smoking During Pregnancy, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_smokingpreg.html&-MaxRecords=all&-DoScript=auto_search_smokingpreg&-search and Smoking and Tobacco Use Prevention, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_smokingprev.html&-MaxRecords=all&-DoScript=auto_search_smokingprev&-search.

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4. ARTICLE PRESENTS FINDINGS ON THE IMPACT OF SUICIDALITY DATA ON PHYSICIAN PRACTICE PATTERNS

"The level of effect on antidepressant prescribing volume observed in our analysis supports the findings reported . . . , suggesting that the number of children and teenagers prescribed antidepressants has decreased dramatically since the October 2003 and March 2004 FDA-issued public health advisories that reported risks of suicidality with the use of antidepressants," state the authors of an article published in the April 2007 issue of the Archives of General Psychiatry. In October 2003, the U.S. Food and Drug Administration (FDA) issued a public health advisory to call attention to reports of the occurrence of suicidality in clinical trials for antidepressants in children and adolescents with depression. In March 2004, the FDA issued a second advisory asking manufacturers to include a warning statement in product labeling that recommends monitoring of adult and pediatric patients for the emergence of suicidality. The authors of the article discuss recent data on the number of children and adolescents prescribed antidepressants (these data indicate that the number has decreased) and provide additional insight into the impact of the pediatric suicidality findings on physician practice patterns.

Data for the analysis were obtained from Verispan, a data set containing prescriptions from a variety of retail channels from a near census of U.S. pharmacies, including information from all payer types (private payer, Medicaid, cash). Focusing on the June 2000 to March 2005 time frame, the researchers tested for significance among observed prescription trends by determining the average monthly percentage change in antidepressant prescribing. Total antidepressant prescriptions were analyzed as a moving quarterly total (a time series aggregate over a 3-month period). A "suicide index" was created to normalize for the differences in prescription volume between individuals ages 18 and younger, those ages 18-25, and those ages 26 and older. To further explore the effect of the reported suicidality data on practice patterns, the researchers also examined data from Verispan's Physician Drug and Diagnosis Audit, a national-level disease and treatment database of approximately 3,400 office-based physicians across 29 specialties. The data were analyzed to better understand changes in specialty physician treatment of children and adolescents (ages 18 and younger) for depression and the antidepressants prescribed.

The authors found that
The authors conclude that "there is need for additional exploration into the relationship between FDA action, media reaction, and physician behavior change to ensure that dissemination of drug safety information does not interfere with appropriate access to care."

Nemeroff C, Kalali A, Keller, M, et al. 2007. Impact of publicity concerning pediatric suicidality data on physician practice patterns in the United States. Archives of General Psychiatry 64(4):466-472. Abstract available at http://archpsyc.ama-assn.org/cgi/content/short/64/4/466.

Readers: More information is available from Bright Futures in Practice: Mental Health at http://www.brightfutures.org/mentalhealth/index.html and What to Expect and When to Seek Help at http://www.brightfutures.org/tools/index.html; and from the MCH Library's knowledge path, Mental Health in Children and Adolescents, at http://www.mchlibrary.info/KnowledgePaths/kp_mentalhealth.html and bibliographies, Adolescent Mental Health, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_adolmenhlth.html&-MaxRecords=all&-DoScript=auto_search_adolmenhlth&-search, Children's Mental Health, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_chldmenhlth.html&-MaxRecords=all&-DoScript=auto_search_chldmenhlth&-search, and Mental Health in Primary Care, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_mental.html&-MaxRecords=all&-DoScript=auto_search_mental&-search.

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5. ARTICLE EXAMINES CHANGING PATTERNS OF INEQUALITIES IN U.S. INFANT, NEONATAL, AND POSTNEONATAL MORTALITY RATES

"The success in reducing absolute disparities in infant mortality must be weighed against changes in the relative measures of disparity, which are particularly important for assessing the progress of various social groups relative to the best-off group toward reaching a health policy goal, such as the elimination of health disparities," write the authors of an article published in the April 2007 issue of Pediatrics Electronic Pages. Infant mortality rates have declined dramatically in the United States over the past 6 decades, yet racial, ethnic, and social class disparities in infant mortality remain marked. Although trends in health inequalities by race and ethnicity, gender, and geographical area are analyzed routinely in the United States, the analysis of changes in the extent of health inequalities over time according to socioeconomic characteristics is far less common. The aim of this article is to examine changes in the extent of inequalities in U.S. infant, neonatal, and postnatal mortality rates between 1969 and 2001 by area of socioeconomic deprivation and maternal education.

The authors analyzed temporal inequalities in infant mortality by linking county-level socioeconomic status (SES) data with birth and death data from the National Vital Statistics System to derive annual infant mortality rates from 1969 to 2000. To estimate SES trends at the individual level, the authors computed infant mortality rates by maternal education using national linked birth and death files.

The authors found that
The authors conclude that "it will be a formidable challenge to meet the 2010 target of 4.5 deaths per 1,000 live births, particularly for infants in the most disadvantaged SES groups, of which the mortality rates would have to be reduced by 50% during this decade."

Singh GP, Kogan, MD. 2007. Persistent socioeconomic disparities in infant, neonatal, and postneonatal mortality rates in the United States, 1969-2001. Pediatrics Electronic Pages 119(4):e928-e939. Abstract available at http://pediatrics.aappublications.org/cgi/content/abstract/119/4/e928.

Readers: More information is available from the MCH Library's knowledge path, Infant Mortality, at http://www.mchlibrary.info/KnowledgePaths/kp_infmort.html, bibliography, Infant Mortality, at http://www.mchlibrary.info/action.lasso?-database=Biblio&-layout=Web&-response=/databases/BibLists/bib_infmortality.html&-MaxRecords=all&-DoScript=auto_search_infmortality&-search, and organizations resource list, Infant Mortality Prevention, at http://www.mchlibrary.info/action.lasso?-database=Organizations&-layout=Web&-response=/databases/OrgLists/orgs_infmort.html&-MaxRecords=all&-DoScript=auto_search_infmort&-search.

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MCH Alert © 1998-2007 by National Center for Education in Maternal and Child Health and Georgetown University. MCH Alert is produced by Maternal and Child Health Library at the National Center for Education in Maternal and Child Health under its cooperative agreement (U02MC00001) with the Maternal and Child Health Bureau, Health Resources and Services Administration, U.S. Department of Health and Human Services. The Maternal and Child Health Bureau reserves a royalty-free, nonexclusive, and irrevocable right to use the work for federal purposes and to authorize others to use the work for federal purposes.
 
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MCH Alert
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